解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Myasthenia gravis (MG) exacerbations may be triggered by infections.In the winter of 2009/2010, the Israeli Ministry of Health recommended that each individual with a chronic condition be vaccinated against both the seasonal influenza and the H1N1 virus. We examined vaccination practices in 74 MG patients. Only 38 pat...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.22077
更新日期:2011-06-01 00:00:00
abstract:INTRODUCTION:Breast cancer is exceptionally associated with anti-collapsin response mediator protein 5 (anti-CRMP5) antibody or demyelinating neuropathy. This paraneoplastic antibody is itself not associated with demyelinating neuropathy. METHODS:Herein we describe a patient with a predominantly sensory ataxic demyeli...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.22036
更新日期:2011-05-01 00:00:00
abstract:INTRODUCTION:Pretreatment with pyridostigmine bromide (PB) of human intercostal muscle fibers exposed to the irreversible acetylcholinesterase (AChE) inhibitor soman was investigated. METHODS:Muscles were pretreated with 3 × 10(-6) M PB or saline for 20 minutes, then exposed to 10(-7) M soman for 10 minutes. RESULTS:...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21922
更新日期:2011-04-01 00:00:00
abstract:INTRODUCTION:Are there electrophysiological findings that predict response to intravenous immunoglobulin (IVIg) in patients with lower motor neuron (LMN) syndromes without multifocal conduction block (MCB)? METHODS:We enrolled 9 patients with LMN syndromes without MCB to receive 18 weeks of IVIg therapy. Response was ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21914
更新日期:2011-04-01 00:00:00
abstract::The purpose of this study was to assess turns/amplitude analysis (TAA) as an objective alternative to conventional qualitative electromyography (EMG) for detection of myopathy in facial muscles. Normal values of TAA parameters were calculated in the frontalis and mentalis muscles of 26 control subjects. We estimated t...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21876
更新日期:2011-03-01 00:00:00
abstract::There is a paucity of validated tests to quantify hand function impairment due to carpal tunnel syndrome (CTS). The aim of this study was to test the validity and reliability of the Purdue Pegboard Test (PPT) in CTS patients. We compared 190 CTS patients with 122 healthy, age-matched controls. CTS severity was determi...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21856
更新日期:2011-02-01 00:00:00
abstract::The purpose of this study was to investigate the influence of an 8-week resistance training program on force steadiness and common drive for the vastus lateralis muscle. Eight untrained men performed a resistance training program. Before the program and at the end of each week, the subjects performed a trapezoid isome...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21836
更新日期:2011-02-01 00:00:00
abstract::Absence of α-actinin-3, encoded by the ACTN3 "speed gene," is associated with poorer sprinting performance in athletes and a slowing of relaxation in fast-twitch muscles of Actn3 knockout (KO) mice. Our first aim was to investigate, at the individual-fiber level, possible mechanisms for this slowed relaxation. Our sec...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21778
更新日期:2011-01-01 00:00:00
abstract::Doxorubicin is a chemotherapeutic agent prescribed for a variety of tumors. While undergoing treatment, patients exhibit frequent symptoms that suggest respiratory muscle weakness. Cancer patients can receive doxorubicin chemotherapy through either intravenous (IV) or intraperitoneal (IP) injections. We hypothesized t...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21809
更新日期:2011-01-01 00:00:00
abstract::Because of their central role in muscle development and maintenance, MEF2 family members represent excellent candidate effectors of the muscle pathology in myotonic dystrophy (DM). We investigated the expression and alternative splicing of all four MEF2 genes in muscle from neuromuscular disorder (NMD) patients, inclu...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21789
更新日期:2010-12-01 00:00:00
abstract::Exercise intolerance with myalgia, muscle stiffness, and recurrent rhabdomyolysis due to mutations in the DMD gene can mimic metabolic myopathies leading to delayed or inaccurate diagnoses. In this retrospective chart review, we report 3 unrelated boys with exertional myalgia, muscle stiffness, myoglobinuria, and norm...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21823
更新日期:2010-12-01 00:00:00
abstract::When an active muscle is stretched, the force increases due to strain of contractile and noncontractile proteins. We examined this force enhancement in rat extensor digitorum longus (EDL) and soleus muscles, which differ in their composition of these proteins, and their susceptibility to damage. Small stretches were a...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21744
更新日期:2010-11-01 00:00:00
abstract::Motor unit action potentials (MUAPs) evoked by repetitive, low-intensity transcranial magnetic stimulation can be modeled as a Poisson process. A mathematical consequence of such a model is that the ratio of the variance to the mean of the amplitudes of motor evoked potentials (MEPs) should provide an estimate of the ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21818
更新日期:2010-11-01 00:00:00
abstract::Case reports and open-label studies suggest that coenzyme Q(10) (CoQ(10)) treatment may have beneficial effects in mitochondrial disease patients; however, controlled trials are warranted to clinically prove its effectiveness. Thirty patients with mitochondrial cytopathy received 1200 mg/day CoQ(10) for 60 days in a r...
journal_title:Muscle & nerve
pub_type: 杂志文章,随机对照试验
doi:10.1002/mus.21758
更新日期:2010-11-01 00:00:00
abstract::We report an 18-month-old Charcot-Marie-Tooth type 1A (CMT1A) patient who developed a rapid-onset neuropathy, with proximal and distal weakness, and non-uniform nerve conduction studies. The neuropathy responded well to immunomodulation, confirming the coexistence of an inherited and an inflammatory neuropathy. Unexpe...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21753
更新日期:2010-10-01 00:00:00
abstract::The compound muscle action potential (M(MAX)) during a maximal voluntary contraction (MVC) may be measured to determine if the motor nerve has been supramaximally stimulated during the interpolated twitch technique (ITT). Ten males performed isometric knee extension MVCs. M(MAX) for the vastus medialis was recorded du...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21692
更新日期:2010-10-01 00:00:00
abstract::Guillain-Barré syndrome (GBS) generally presents sporadically. Epidemics of GBS are unusual. We reviewed the medical records of 26 patients hospitalized for GBS during the 2007 GBS epidemic in northeast China. The objective was to determine whether there were clinical and electrophysiological characteristics. All pati...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21701
更新日期:2010-09-01 00:00:00
abstract::Heterozygous mutations in the Berardinelli-Seip congenital lipodystrophy (BSCL2) gene have been associated with different clinical phenotypes including Silver syndrome/spastic paraplegia 17, distal hereditary motor neuropathy type V, and Charcot-Marie-Tooth disease type 2 (CMT2) with predominant hand involvement. We s...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21734
更新日期:2010-09-01 00:00:00
abstract::A stand-alone ultrasound shear wave imaging technology has been developed to quantify and visualize Young's modulus distribution by remotely applying ultrasound radiation force and tracking the resulting microvibrations in soft tissues with ultrafast ultrasound imaging. We report the first preliminary data that detect...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21723
更新日期:2010-09-01 00:00:00
abstract::Daptomycin is a lipopeptide antibiotic with strong bactericidal effects against Gram-positive bacteria and minor side effects on skeletal muscles. The type and magnitude of the early effect of daptomycin on skeletal muscles of rats was quantified by histopathology, examination of contractile properties, Evans Blue Dye...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21691
更新日期:2010-09-01 00:00:00
abstract::Nerve conduction studies (NCS) may be deferred because of a perceived risk of cardiac arrhythmia in the presence of same-limb peripheral intravenous lines. Patients with implanted pacemakers or defibrillators provide a model in whom this risk can be assessed. Twenty patients, seven with pacemakers and 13 with defibril...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21714
更新日期:2010-08-01 00:00:00
abstract::Charcot-Marie-Tooth (CMT) disease is a heterogeneous group of inherited sensory and motor neuropathies. Mutations in the gene that encodes for myelin protein zero (MPZ) can produce different phenotypes: CMT1 (with low conduction velocities), CMT2 (less frequent and with unaffected conduction velocities), and CMTID (wi...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21643
更新日期:2010-08-01 00:00:00
abstract::To define numerically the clinical severity of facioscapulohumeral muscular dystrophy (FSHD), we developed a protocol that quantifies muscle weakness by combining the functional evaluation of six muscle groups affected in this disease. To validate reproducibility of the protocol, 69 patients were recruited. Each patie...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21671
更新日期:2010-08-01 00:00:00
abstract::Several approaches to treat laminin alpha2 chain-deficient congenital muscular dystrophy (MDC1A) in mouse models have been undertaken. Most have shown promising results in young animals. However, older animals have only been characterized to some extent. Herein we analyze the lifespan of laminin alpha2 chain-deficient...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21616
更新日期:2010-07-01 00:00:00
abstract::It is important to know the effects of prolonged repetitive nerve stimulation (RNS) when it is used in neurophysiological studies. RNS with up to 100 supramaximal stimuli was given to the median, ulnar, and peroneal nerves of normal subjects and the ulnar nerves of subjects with early amyotrophic lateral sclerosis (AL...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21604
更新日期:2010-06-01 00:00:00
abstract::A 3-month-old boy with hypotonia at birth succumbed to a congenital myopathy. The major finding in his muscle biopsy corresponded to I-Z-I complexes described previously in embryonic skeletal muscle. A few previous myopathy cases have described findings suggestive of I-Z-I-like complexes. A mutation affecting mononucl...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21575
更新日期:2010-05-01 00:00:00
abstract::Neuromuscular recovery after peripheral nerve lesion depends on the regeneration of severed axons that re-establish their functional connection with the denervated muscle. The aim of this study was to determine the effects of electrical stimulation (ES) on the neuromuscular recovery after nerve crush injury in rats. E...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21549
更新日期:2010-05-01 00:00:00
abstract::L1 radiculopathy is very rare and difficult to diagnose with needle electromyography. A patient presented with pain and hypesthesia on the anterolateral aspect of the left thigh. Nerve conduction studies and needle electromyography were normal, except for the quadratus lumborum and iliopsoas muscles, which showed abno...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21601
更新日期:2010-04-01 00:00:00
abstract::We report the case of a 55-year-old man with non-small-cell lung cancer who underwent radiation, chemotherapy with carbotaxol and paclitaxel, and left upper lobe removal 2 years prior to evaluation. He was referred for disabling orthostatic hypotension (113/69 mm Hg supine and 66/47 mm Hg standing after 10 minutes) wi...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21528
更新日期:2010-03-01 00:00:00
abstract::Piriformis syndrome (PS) is a rare condition characterized by pain and paresthesia of the buttock, often radiating to the posterior thigh. A patient with sciatica that was clinically suspicious for PS, underwent diagnostic work-up. A diagnosis of diffuse large B-cell lymphoma with neurolymphomatosis (NL) was made. To ...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21538
更新日期:2010-03-01 00:00:00
abstract::Muscle-derived neurotrophins are thought to contribute to the adaptation of skeletal muscle to exercise, but the effects of brief exercise interventions on BDNF, NT-4/5, and trkB are not understood. RNA was extracted for RT-PCR from soleus and medial gastrocnemius of Sprague-Dawley rats exercised on a treadmill at spe...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21503
更新日期:2010-03-01 00:00:00
abstract::Sprengel's deformity is the most common congenital deformity of the shoulder. A known complication of correcting this deformity is brachial plexus palsy. In this study we used somatosensory evoked potential (SSEP) monitoring during correction of a Sprengel's deformity and identified an early iatrogenic brachial plexus...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21545
更新日期:2010-02-01 00:00:00
abstract::Statins can induce necrotizing or inflammatory myopathies in some patients. Increased major histocompatibility complex class I (MHC I) expression has been shown in muscle biopsies of statin-induced myopathy. Therefore, we investigated the effect of statins on the expression of MHC I in muscle cells. Using flow cytomet...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21479
更新日期:2010-02-01 00:00:00
abstract::Clinicians who use electromyographic (EMG) signals to help determine the presence or absence of abnormality in a muscle often, with varying degrees of success, evaluate sets of motor unit potentials (MUPs) qualitatively and/or quantitatively to characterize the muscle in a clinically meaningful way. The resulting musc...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21456
更新日期:2010-01-01 00:00:00
abstract::Skeletal muscle cells are hypertrophied by mechanical stresses, but the underlying molecular mechanisms are not fully understood. Two signaling pathways, phosphatidylinositol 3-kinase (PI3K)/Akt to target of rapamycin (TOR) and extracellular signal-regulated kinase kinase (MEK) to extracellular signal-regulated kinase...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21473
更新日期:2010-01-01 00:00:00
abstract::Ultrasound has been used for visualizing peripheral nerve pathology. Our goal was to use ultrasound to quantitate the sizes of upper extremity nerves along their length in control subjects and patients with neuropathy. We measured median and ulnar nerve cross-sectional areas (NCSA) in the arms of 190 subjects, includi...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21431
更新日期:2009-12-01 00:00:00
abstract::Influenza vaccination has been associated with adverse events including Guillain-Barré syndrome. Because the safety of influenza vaccination in patients with myasthenia gravis (MG) has not been established, some clinicians discourage vaccination for these patients. We explored whether the administration of influenza v...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21440
更新日期:2009-12-01 00:00:00
abstract::In this study we investigated the gene expression of proteins related to myostatin (MSTN) signaling during skeletal muscle longitudinal growth. To promote muscle growth, Wistar male rats were submitted to a stretching protocol for different durations (12, 24, 48, and 96 hours). Following this protocol, soleus weight a...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21426
更新日期:2009-12-01 00:00:00
abstract::Nerve guides seeded with Schwann cells (SCs) promote axonal regeneration in peripheral nerve lesions. We examined the applicability of bioluminescent imaging (BLI) for monitoring the fate of SCs in nerve guides after implantation. Rat SCs were transfected with the firefly luciferase (Fluc) gene and subsequently seeded...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21372
更新日期:2009-11-01 00:00:00
abstract::In this study we present 3 families with malignant hyperthermia (MH), all of Indian subcontinent descent. One individual from each of these families was fully sequenced for RYR1 and presented with the non-synonymous change c.11315G>A/p.R3772Q. When present in the homozygous state c.11315*A is associated with myopathic...
journal_title:Muscle & nerve
pub_type: 杂志文章
doi:10.1002/mus.21397
更新日期:2009-10-01 00:00:00